The amygdala is a part of the human brain within the temporal lobe. This part of the brain controls the fight or flight response, the release of cortisol and adrenaline, and signals to the hippocampus to store memories associated with high levels of stress or joy.
(LeDoux )
Experiencing a traumatic and stressful event, or series of traumatic and stressful events can lead to the amygdala becoming overactive. This overactivity in the amygdala leads to excessive cortisol in the body, and even increased adrenaline. This can cause many different changes both physically and mentally.
Increased cortisol production can cause weight gain and an inability to lose weight regardless of diet and exercise. Cortisol is the body's primary stress hormone. It changes the body by suppressing functions that are nonessential in a dangerous or stressful situation such as the digestive and reproductive systems. (Mayo Clinic Staff)
Adrenaline causes the heart rate to increase, and raises blood pressure in an attempt to give you energy and strength to survive the dangerous or stressful situation. Chronic stress and fear can cause heart problems. Adrenaline also increases your glucose levels, which can lead to conditions such as diabetes. (Mayo Clinic Staff)
The amygdala becoming overactive causes these natural responses to go crazy, producing mental and physical illness from anxiety and depression to heart disease and stroke. People experiencing an overactive amygdala also have problems with memory and focus. (Mayo Clinic Staff)
An overactive amygdala leads to anxiety disorders, ptsd,and depression. Trauma can cause mental illness by forcing the amygdala to overwork, causing it to become overactive. This type of dysregulated fear response leads to behavioral issues. “Several lines of evidence indicate that the amygdala plays a prominent role in the pathophysiology of anxiety disorders and depression.” - The National Library of Medicine.
Works Cited
LeDoux, Joseph. “The Amygdala.” Current Biology, vol. 17, no. 20, 2007. Cell Press, https://www.cell.com/current-biology/fulltext/S0960-9822(07)01779-4. Accessed 30 April 2026.
Mayo Clinic Staff. “Chronic stress puts your health at risk.” Mayo Clinic, 2023, https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20046037. Accessed 30 April 2026.